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The carpal tunnel syndrome is commonly seen in patients who have received haemodialysis for a long time.Compression of the median nerve,flexor tenosynovitis,and destructive arthropathies are associated with hypertrophic material,which generally contains amyloid derived from B2 microglobulin.The pathogenesis of the syndrome is unknown,although possibly the dialysis membrane has an effect.The syndrome has been reported in patients treated with cellulose membranes non-permeable to B2 microglobulin.The prevalence of the syndrome increases with the duration of dialysis,and nearly all patients treated for more than 18 years require a decompression operation.Few data have been reported on the occurrence of amyloidosis due to dialysis in patients treated with synthetic membranes permeable to B2 microglobulin.Since the early 1970s we have used the highly permeable polyacrylonitrile AN 69 membrane for dialysis.we report the prevalence of the syndrome in our patients. |
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